It's difficult not to check at least one bag, with all the liquid restrictions these days. Unless you don't mind buying new shampoo/conditioner/contact solution/moisturizer/whatever else you need at your destination (which can be quite costly if you're flying international). I usually try to avoid checking bags, but I've never had anything that effed up happen before.
I don't carry any of those things with me. The only thing that could potentially cause trouble is toothpaste, and I have a special travel-sized container specifically for that purpose.
Incidentally, with all the fees being levied on checked bags these days, it seems like almost everyone is trying to carry on their luggage instead, which is sensible. But it makes boarding take forEVER. Everyone is dragging suitcases and duffel bags that are too large for the overhead compartments, and then they stand in the aisles blocking the flow of traffic trying to stuff their huge suitcase in the bins.
Yeah. I have a duffel bag that fits in all overhead compartments of planes I've flown in (and I flew out of the tiny Roanoke airport for a while, so I've flown in some small planes). It holds a week's worth of clothes and my toiletries just fine. If I'm traveling for business I'll generally use my laptop case as my personal item (which may mean that I need to store books in the duffel bag as well), otherwise I'll use a backpack that holds my books, electronic gadgets, and laptop.
There's no good solution unless regulations change...air travel is becoming increasingly unpleasant. It's gotten to the point that I would definitely rather drive 10 hours to visit my family than fly for 3.
It would take a fairly cataclysmic event to get me to drive 10 hours by myself (which, since I'm not married, is the default option). Southwest Air has a major hub in RDU so I can often get a cheap flight where I'm treated like a human being. Last time I went up to visit my mom's family, over 8 hours away, I think it cost me under $300 round-trip. Able to kick back and read for a few hours instead of battling my way up I-77 for half the day? Yeah, I'm a fan. A pair of noise-canceling headphones and a couple of good books and I'm good to go.