Thanks everyone, for your empathy and words of advice and offers to pray. Some specific comments:
You seem to be aware of this already, but be very very careful about long-term use of medication. This is one case where the cure is very much worse than the disease when taken over long periods of time.
I've told her that I hope this medication isn't something that she'll need to be on forever - the idea is to ramp down as your mood begins to stabilize, to the point where you can safely stop taking the medication. I do know that these things are a bit of a crapshoot - I have a friend who is a pharmacist and who has explained that one body may react differently to a certain molecule than another. So it's a bit of trial and error for doctors trying to figure out which anti-depressant will help their patient - and some do run the risk of making your mood swing even wider than it otherwise would. It's something that has to be monitored carefully, so whenever she expresses some of these extreme thoughts, I tell her to make sure she's reporting this stuff back to her doctor
and her therapist.
The articles you linked to are pretty long, so I'll have to take those in later.
First, I kicked caffeine. As I saw it, the best way to make my brain work the way it's supposed to was to eliminate the chemicals that I used to alter the way it worked.
This step is more or less already done - my wife hates coffee, rarely ever touches a caffeinated soda, and usually drinks decaffeinated teas. If she ever takes in any caffeine, it's in the occasional non-decaf tea, or in chocolate, which is a minimal amount compared to caffeinated beverages. She never uses energy drinks or pills to keep herself awake. She's just never been big on most caffeinated things. Given this information, you'd think I'd be the one who was depressed (though a much larger caffeine intake at other times in my life does help to explain some of my bouts with it).
After that horrible, horrible week, I set up a regimented sleep schedule. Different people need different amounts of sleep, and I discovered that without caffeine the amount that I needed was above average.
That's interesting, given that she's not a caffeine addict and never has been. She can easily sleep 10 or 11 hours on a regular basis, though I don't know how solidly she's sleeping through the night. I've heard that women require more sleep than men on average, but this still seems like an extreme amount to me. On a day when she doesn't have anywhere important to me and we don't come up with anything particularly interesting to do, she'll sleep in until 10 or 11, come back in the afternoon after we have lunch out or whatever and take a nap for several hours, and still conk out between 9 and 10 in the evening. Her normal work day is about a 4-hour shift that starts at 8 or so in the morning; she gets up a little before 7 on weekdays to get there on time, and presumably takes a nap most afternoons when she gets off work. It's very rare for her to have a day during which she doesn't complain about feeling tired.
Rather than forcing myself into an unnatural sleep schedule just to give myself more time in the day (time which would be spent in a hazy, agitated state), I decided to just roll with it. I discovered that naturally I tend to fall asleep between 11:30 and 12:30 in the evening and wake up sometime between 8 and 9. This schedule is already conducive to a normal (well, computer-science-normal) lifestyle. It's the schedule I have maintained to this day; I rarely wake up to an alarm and I rarely have trouble falling asleep. I also never need or take a nap in the middle of the day.
She tends to go with the "sleep when tired" approach, as do I. I naturally get tired much later in the evening (computer-science-to-the-extreme, I guess), and wake up much later, and I have my own sleep issues which probably affect my mood at times, too. But my wife isn't usually forcing herself to stay awake well past the point when she starts feeling tired. She feels tired and generally doesn't fight it. I've caught her falling asleep in church (which starts at 11:30, so it's not like we're getting up way early to get there on time) and at Bible Study (which tends to run 7:30 - 10-ish in the evening), so sit her down pretty much anywhere other folks are talking and she's just listening, and she'll conk out if not actively engaged in the discussion.
I also decided to take time to let my mind recover.
I'd love to recommend that she try this; I just don't know where to tell her to go that would be relaxing. Our immediate neighborhood is pretty noisy and irritating, and she doesn't have a car.
In addition to this, I resolved to ride my bike more for transportation rather than driving or riding the bus. A bike ride is a slower pace so the mind isn't always on edge trying to keep from dying in an auto accident, there aren't the frustrations of traffic, and a level of low-grade exercise is good for serotonin levels without exhausting the brain and causing adrenaline levels to increase.
She walks to work and back every day. It's less than a mile. She has a bike and could ride it to work and save time, but for whatever reason, she doesn't.
It's hard to get out of a depression. This is especially the case in our modern society, because so much of what we do involves around constant brain stimulation, and that's not at all what we're designed for. Watching TV or even reading can be too much stimulation for an already overstimulated mind, but when your brain is all revved up it's hard to do what it is you need the most, which is a slow walk through the park or a quarter-hour rest on a park bench.
This seems to be more my problem than hers; I'm always looking for something to keep my brain active, and I catch myself walking too fast during what's supposed to be a slow, romantic walk in the park or whatnot because my mind's already on the next thing I'm gonna do that day. She takes life at a slower pace quite well when allowed the time and space to do so. Most days, she doesn't have to rush to get from one place to the next - she may have to get up early for work, but it's a half day and she's got a lot of leisure time before she has to be at her one evening class per week, and plenty of time during the week to get the homework done (though she has a learning disability, so the homework does take her a lot longer than it would most folks).
The other weird thing that science isn't quite able to explain is how effectiveness rates of antidepressants are plummeting and the effectiveness of placebos is increasing.
Makes me wonder if we develop an immunity to these things over time, kind of like how diseases develop resistance to vaccines. You're ingesting a chemical that is designed to correct your brain chemistry in some way, but there are cases in which the problem can come back with a vengeance when you go off of that drug and the system gets thrown off again.
The placebo thing doesn't surprise me - it's a psychological problem, so believing you're taking something that's going to help you may affect the physical state of your brain more than something that actually messes with its chemistry, at least for some people. Probably harder to accomplish that in a skeptic like myself, but then, knowing there's no magic bullet and it's just a process that takes time actually helps me to take time and not constantly berate myself for being in a funk.
What I read into this isn't that you should start feeding your wife sugar pills to ease her depression but that a positive attitude is as important as medication when treating depression.
I usually try to be encouraging, but I'll admit sometimes I'm weak and just sick of hearing about the same crisis day in and day out, and that's when I come down on her and make it about what she's doing to
me. That probably isn't helpful, but dammit, I'm pissed.
I've also found that what helps me is, as the Scientific American article I linked earlier suggests, is to enumerate my problems, break them into chunks, and write them all down.
I've sort of recommended this. A whole semester of this class is overwhelming? Handle it one homework assignment and one test at a time. (Honestly, some folks work full-time
and go to school - she's down to half-time work and quarter-time school. It's only overwhelming to her because it's any work at all.) Learning to drive is overwhelming? Take it one lesson and one function at a time. (We have a very patient friend who has been giving her free lessons, but she's put that on hold for whatever reason.) It seems to go in one ear and out the other.
I know that phorumers are already smart enough to take the advice of Random Internet Dude with the grainmountain of salt it deserves, but it's always worth reiterating.
You're a Random Internet Dude that I've known for several years now; I weight your opinions a little more heavily than that, without assuming you know everything. I know enough to be sure that the sum of your knowledge is nonzero.
Honestly I can't pinpoint one thing that made me leap out of depression. When I get stressed (i.e. right now) I do tend to feel depression pulling at me. When I was in high school, I don't know exactly what triggered it or why it got so bad, but I do know that I had to give myself a kick in the pants to break free from it. It's strange, but you do get to the point where depression becomes part of your identity and it is really difficult to realize that it is not, actually, a friend.
I too can remember what it was like to get so depressed for so long that I just assume this is my lot in life from now on and I can never go back to the optimist I used to be. It's not the truth, but I know it can look like there's no way out of it when you're in it, so I do keep that in mind.
For what it's worth, I blogged about the subject last night, using the lens of depressions I'd previously been through as a way to empathize with those currently going through it, in a way that I hope was vague enough to not out my wife. Going over my past depressions and trying to pinpoint the things that brought me out of it has been an intriguing exercise. Those times in my life make so much sense to me now, but they seemed so chaotic back then.
http://murlough23.xanga.com/716213625/the-great-depression/David - I've been where you are. My wife has had a couple of serious bouts of depression/anxiety. To be honest, the first time she used a mix of counseling and short-term medication (11 months) to break the cycle. It reared its ugly head again when our daughter was born this year (postpartum depression), but we recognized the signs a lot sooner. She still took medicine for about 5 months, though.
This actually brings up one of my worst fears - that my wife will get the one thing she wanted most out of life (to be a mother) and
still not be happy. I know giving birth can mess with a woman's chemistry - your body has producing all of these loving, nurturing, bonding hormones for 9 months and suddenly it stops because you're no longer physically connected to your child, and CRASH. Knowing this is supposed to be a huge happy blessing and yet still feeling so hopeless only makes it worse. If normal women who otherwise don't get depressed are susceptible to this, then boy, this is gonna be a doozy for her when the time comes. Personally, I would like to have children but I don't look at it as the be-all-end-all answer to my happiness. I think it'll be a lot of work and a lot of little things that will surprise and bless me, and in the end I'll be glad for the accomplishment of bringing a child up and the relationship I'll have with that little person. But when I have a ton of responsibilities suddenly added to my daily life, that tends to stress me out, so it's really going to me a time that I'll need her to be strong and lead the way. If I can't see that making this dream come true for her has truly brought her some level of lasting happiness, then I'm gonna feel like, "Why did we bother having a kid?" Because my main thing is that wanting her dreams to come true is what will make mine come true. She already married me. That was my biggest dream. So now I just want her to be happy.
We're not fans of the medicine, though. What helped more than anything was her having people she could talk to who had been through depression - or were working their way out of it, too.
A few folks have responded to my blog entry indicating that they've been through it before.
This was frustrating for me, because I'm the farthest thing from depressed - I'm probably clinically optimist.
Damn you.

It's hard for me to understand how depression works, and it took a lot for me to just be there the best I could.
Honestly, if I hadn't been through depressions myself, we would have never gotten married. I knew she was prone to it, and my mother actually warned me when I mentioned I was considering proposing, saying, "What if you have a baby and she goes into a deep depression?", and I think that would have scared me off if I didn't know what it was like to go through it myself. I made that choice knowing I was committing myself to seeing her through it if and when it happened. Given how bad I was the first few months we were married, I do kind of owe her one.
I'll be praying for y'all. I don't have the answer to your wife's situation, and I know how hard it is to be the observer who wants to "fix it." You can't. You can encourage her, but the healing can't come from you. Which sucks.
Yeah, that's the worst part. I'm more of an empowerer than a fix her - I want to give her the tools to come out of it on her own. Pointing her to other people who can probably be more empathetic than I currently can is probably a good way to go.